Endothelial to mesenchymal transition is common in atherosclerotic lesions and is associated with plaque instability
نویسندگان
چکیده
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منابع مشابه
Corrigendum: Endothelial to mesenchymal transition is common in atherosclerotic lesions and is associated with plaque instability
Endothelial to mesenchymal transition (EndMT) plays a major role during development, and also contributes to several adult cardiovascular diseases. Importantly, mesenchymal cells including fibroblasts are prominent in atherosclerosis, with key functions including regulation of: inflammation, matrix and collagen production, and plaque structural integrity. However, little is known about the orig...
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The molecular mechanisms responsible for the development and progression of atherosclerotic lesions have not been fully established. Here, we investigated the role played by endothelial-to-mesenchymal transition (EndMT) and its key regulator FGF receptor 1 (FGFR1) in atherosclerosis. In cultured human endothelial cells, both inflammatory cytokines and oscillatory shear stress reduced endothelia...
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BACKGROUND Leukocyte migration is critical for the infiltration of monocytes and accumulation of monocyte-derived macrophages in inflammation. Considering that Hck and Fgr are instrumental in this process, their impact on atherosclerosis and on lesion inflammation and stability was evaluated. METHODS AND RESULTS Hematopoietic Hck/Fgr-deficient, LDLr(-/-) chimeras, obtained by bone marrow tran...
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عنوان ژورنال:
دوره 7 شماره
صفحات -
تاریخ انتشار 2016